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 Carl-Etienne Juneau posted on Friday, March 11, 2011 - 2:05 pm
Dear Dr. Muthén,
Dear Dr. Muthén,

I've just found out about this forum. I've read 2-3 threads, and I must say I'm impressed by the level of service you provide to the community. My hat off to you.

I have a question. But before, a few observations:

1. Longitudinal data sets are hierarchical (observations nested within subjects).

2. Therefore, in longitudinal data sets, observations are not independent.

3. SEM treats all observations as independent.

4. Therefore, SEM is not appropriate for longitudinal data.

My questions:

a. Is this reasoning correct?

b. If yes, are multilevel SEM the solution?

c. If no, do I need to take special measures when specifying my models to account for longitudinal data?

Thanks so much!

Carl-Etienne Juneau
PhD candidate in public health
Université de Montréal
 Linda K. Muthen posted on Monday, March 14, 2011 - 4:15 pm
a. No.
c. Taking a multivariate approach to growth modeling, with data in the wide format where each time point is represented by one variable, takes into account the non-independence of observations due to repeated measures.
 Virginia Warner posted on Friday, March 18, 2011 - 2:42 pm
What about correlations within families?
 Linda K. Muthen posted on Friday, March 18, 2011 - 2:58 pm
If you have sampled family members from a random set of families, generally one would use multilevel modeling with family as the cluster variable. If there are not too many family members, one could take a multivariate approach as described in:

Khoo, S.T. & Muthn, B. (2000). Longitudinal data on families: Growth modeling alternatives. Multivariate Applications in Substance use Research, J. Rose, L. Chassin, C. Presson & J. Sherman (eds.), Hillsdale, N.J.: Erlbaum, pp. 43-78.
 Andrea Norcini Pala posted on Friday, April 19, 2013 - 12:43 am
Hi,

I have three time point measurment of biomarkers about Illness progression.
does it make sense to you using these three measurements as indicators of a latent dimension? Namely, let's say I have three assessements of viral load (baseline, time 1 and time 2), may I consider them indicators of a latent dimension "viral load change over the time"?

if so, can you suggest papers where this approach has been adopted?

Thank you very much,
Andrea
 Bengt O. Muthen posted on Friday, April 19, 2013 - 5:05 pm
If you have a notion of illness progression, perhaps a growth model would be suitable. That explores the individual variation in both the level and the change over time. See our Topic 3 handout and video on our website.

A growth model is a specific kind of a latent variable model.
 Andrea Norcini Pala posted on Saturday, April 20, 2013 - 12:24 am
Thank you very much!
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