Randomized Trials

Mplus provides new methods for the analysis of data from randomized trials (clinical trials, randomized preventive interventions):

Complier-average causal effect (CACE) modeling--assessing treatment effects among compliers in the treatment group as compared to potential compliers in the control group. Mplus setup for CACE modeling. Mplus Examples.

• The basics of CACE analysis. Free online course by Booil Jo and Liz Stuart. The course is targeted at an applied audience interested in the application of the CACE method.
  
  
• Sobel, M. & Muthén, B. (2012). Compliance mixture modelling with a zero effect complier class and missing data. Biometrics, 68, 1037-1045. DOI: 10.1111/j.1541-0420.2012.01791.x
  
  
• Jo, B., Asparouhov, T. & Muthén, B. (2008). Intention-to-treat analysis in cluster randomized trials with noncompliance. Statistics in Medicine, 27(27), 5565-5577. DOI: 10.1037/met0000239
  
  
• Jo, B. (2002). Estimation of intervention effects with noncompliance: Alternative model specifications. Journal of Educational and Behavioral Statistics, 27(4), 385-409. DOI: 10.3102/10769986027004385
  
  

Growth mixture modeling--allowing treatment effects to vary across latent trajectory classes and among individuals within classes. View setup for growth mixture modeling.

• Muthén, B., Brown, C.H., Hunter, A., Cook, I.A. & Leuchter, A.F. (2011). General approaches to analysis of course: Applying growth mixture modeling to randomized trials of depression medication. In P.E. Shrout (ed.), Causality and Psychopathology: Finding the Determinants of Disorders and their Cures (pp. 159-178). New York: Oxford University Press.
  
  
• Muthén, B. & Brown, H. (2009). Estimating drug effects in the presence of placebo response: Causal inference using growth mixture modeling. Statistics in Medicine, 28(27):3363-85.DOI: 10.1002/sim.3721
  
  
• Muthén, B., Brown, C.H., Masyn, K., Jo, B., Khoo, S.T., Yang, C.C., Wang, C.P., Kellam, S., Carlin, J., & Liao, J. (2002). General growth mixture modeling for randomized preventive interventions. Biostatistics, 3, 459-475. DOI: 10.1093/biostatistics/3.4.459 Mplus inputs and outputs.

For more information, visit our General Description page.

For more papers see our Randomized Trials paper topics.